10 Best Newsletters to Prevent Brain Rot in 2025

Quarterly

ABS-201: AI-Designed Injectable for Regrowth and Anti-Graying

Absci's AI-generated drug ABS-201 targets the telogen (shedding) phase directly, bypassing initial hair loss from minoxidil. It reactivates follicles and repigments hair, with preclinical data showing reversal in balding models. Phase 1 human trials launched mid-2025; could hit market by 2028.

Absci Corporation

AI

Longevity Escape Velocity

Longevity Escape Velocity

Bi-Annual

ET-02 Topical: Metabolic Switch for Androgenic Alopecia

Eirion Therapeutics' ET-02 flips a metabolic pathway in follicle cells, outperforming existing drugs in Phase 1 (N=24) with 2x hair density gains. Prevents greying too; Phase 2 (N=150) starts Q1 2026. Targets 80M US sufferers, with potential for prevention.

Eirion Therapeutics

Metabolic Pathway

Longevity Escape Velocity

Longevity Escape Velocity

Monthly

AMP-303: Single-Cycle Follicle Signal for Regrowth

UC Irvine's injectable AMP-303 sends a 'print signal' to dormant follicles, yielding 15%+ increase in thick hair after one treatment (vs. placebo). Effects last 150+ days; addresses recent and long-term loss. Phase 2 trials ongoing, with human data from 2025 study.

Amplifica Holdings Group & UC Irvine

Longevity Escape Velocity

Stem Cell

Annual

Stem Cell-ATP Combo: 100% Reversal in Preclinical Models

Madrid's San Carlos Hospital combined fat-derived stem cells with ATP (energy molecule) to reverse pattern baldness in mice males regrew fur, 90% females fully revived. Human trials planned for 2026; focuses on follicle energy dysfunction.

Hospital San Carlos (Madrid) Research Team

Longevity Escape Velocity

Hair Loss

Innovation & Research

Bi-Annual

Upper Follicle Stem Cells: Key to Bald Scalp Revival

UVA discovered latent stem cells persist in bald scalps; depleting them halts growth, but reactivating could repopulate follicles. Lab tests on human samples show migration potential for regrowth; early-stage, but paradigm-shifting for scarring alopecia.

University of Virginia School of Medicine

Longevity Escape Velocity

Innovation & Research

Quarterly

Microneedle Immunomodulators: Reversal for Autoimmune Hair Loss

MIT's microneedle patch delivers drugs to restore immune privilege in follicles, reversing alopecia areata in mice (full regrowth). Human trials via Phase 1 in 2025; targets autoimmune-driven loss, not just pattern baldness.

MIT

Autoimmune Disease

Science & Discovery

Longevity Escape Velocity